The paper identifies age-associated Th2-like CD8 memory T cells in human blood and links their accumulation to health conditions like asthma and diabetes.

Aging Cell · Feb 1, 2026Peer-reviewedImmunology

Integrative epigenetics and transcriptomics identify aging genes in human blood

Mahdi Moqri, Kejun Ying, Jesse R. Poganik, Chiara Maria Stella Herzog, Qingwen Chen, Mehrnoosh Emamifar, Alexander Tyshkovskiy, Alec Eames, Jure Mur, Dmitrii Glubokov, Benyamin Matei-Dediu, Ludger J.E. Goeminne, Wayne Mitchell, Daniel L. McCartney, Lucas A. Salas, , Vadim N. Gladyshev

This study identifies aging genes in human blood by integrating epigenetic and transcriptomic data, finding genes enriched for immune functions that better replicate across populations and link to aging outcomes.

Nature Communications · Jan 19, 2026Peer-reviewedSystems Biology

Network Analysis Reveals Protein Modules Associated with Childhood Respiratory Diseases

Nicole Prince, Sofina Begum, Kevin M. Mendez, Lourdes G. Ramirez, Yulu Chen, Qingwen Chen, Su H. Chu, Priyadarshini Kachroo, Ofer Levy, Joann Diray‐Arce, Paolo Palma, Augusto A. Litonjua, Scott T. Weiss, Rachel S. Kelly, Jessica Ann Lasky-Su

The paper uses WGCNA to identify protein modules in 1-year-old children linked to respiratory diseases by age 6, showing associations with environmental and metabolomic factors.

Journal of Allergy and Clinical Immunology · Jul 1, 2025Peer-reviewedBioinformatics

High-dimensional Ageome Representations of Biological Aging across Functional Modules

Kejun Ying, Alexander Tyshkovskiy, Qingwen Chen, Eric Latorre Crespo, Bohan Zhang, Hanna Liu, Benyamin Matei-Dediu, Jesse R. Poganik, Mahdi Moqri, Kristina Kirschne, Jessica Ann Lasky-Su, Vadim N. Gladyshev

This paper introduces Ageome, a framework to measure epigenetic age across molecular pathways in mice and humans, revealing pathway-specific aging patterns and heterogeneity in mortality prediction.

bioRxiv · Sep 17, 2024 · PreprintSystems Biology

A genome-wide association study of mass spectrometry proteomics using the Seer Proteograph platform

Karsten Suhre, Qingwen Chen, Anna Halama, Kevin M. Mendez, Amber Dahlin, Nisha Stephan, Gaurav Thareja, Hina Sarwath, Harendra Guturu, Varun Bhamidipati Dwaraka, Serafim Batzoglou, Frank Schmidt, Jessica Ann Lasky-Su

This study performs a genome-wide association study using mass spectrometry proteomics to identify pQTLs, finding that epitope effects may affect some affinity proteomics results while confirming others.

bioRxiv · May 27, 2024 · PreprintGenomics

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records

Qingwen Chen, Varun Bhamidipati Dwaraka, Natàlia Carreras-Gallo, Kevin M. Mendez, Yulu Chen, Sofina Begum, Priyadarshini Kachroo, Nicole Prince, Hannah Went, Tavis L. Mendez, Aaron Lin, Logan Turner, Mahdi Moqri, Su H. Chu, Rachel S. Kelly, , Jessica Ann Lasky-Su

The paper develops OMICmAge, a multi-omics biomarker of biological age, and shows it outperforms existing markers in predicting chronic diseases and mortality.

bioRxiv · Oct 16, 2023 · PreprintBioinformatics

A meta-analysis of immune cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes

Qi Luo, Varun Bhamidipati Dwaraka, Qingwen Chen, Huige Tong, Tianyu Zhu, Kirsten Seale, Joseph M. Raffaele, Shijie Zheng, Tavis L. Mendez, Yulu Chen, Natàlia Carreras-Gallo, Sofina Begum, Kevin M. Mendez, Sarah Amandine Caroline Voisin, Nir Eynon, , Andrew Erich Teschendorff

This paper uses DNA methylation data to analyze immune cell fractions across 25,629 blood samples, identifying associations with age, sex, health outcomes, and lifestyle factors.

Genome Medicine · Jul 31, 2023Peer-reviewedBioinformatics