Profiling of HCAR1 signaling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist
Simon Lind, Shane C. Wright, Emilia Gvozdenović, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson
This study identifies and characterizes synthetic ligands for HCAR1 using ebBRET, revealing its activation of Gi/o and Gs pathways without β-arrestin recruitment.
bioRxiv · May 2, 2025 · PreprintPharmacology & Toxicology