Author

Shane C. Wright

Karolinska InstitutetORCID 0000-0002-7470-5068Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Ahmed M. AbdelmoeziD· 1 shared Aidan J. BradyiD· 1 shared Anna KrookiD· 1 shared Brendan M. GabrieliD· 1 shared Emilia Gvozdenović· 1 shared Jonathon A. B. SmithiD· 1 shared Juleen Rae ZierathiD· 1 shared Kenneth L. GranbergiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Ahmed M. AbdelmoezORCID

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2 papers

Recent·Most cited

Cell BiologyMolecular MetabolismPeer-reviewedJul 2, 2025

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

Jonathon A. B. Smith, Brendan M. Gabriel, Aidan J. Brady…·Nicolas J. Pillon

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

11 citations

humanbulk RNA-seq

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Pharmacology & ToxicologybioRxivPreprintMay 2, 2025

Profiling of HCAR1 signaling reveals Gαi/o and Gαs activation without β-arrestin recruitment and the discovery of an allosteric agonist

Simon Lind, Shane C. Wright, Emilia Gvozdenović…·Linda C. Johansson

This study identifies and characterizes synthetic ligands for HCAR1 using ebBRET, revealing its activation of Gi/o and Gs pathways without β-arrestin recruitment.

2 citations

humanproteomics

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