Orally available designed miniproteins inhibit enterotoxigenic Bacteroides fragilis pathology by blocking toxin receptor binding
Pooja Srinivas, Victor Adebomi, Susan M. Markiewicz, Kang Wang, Denise Chac, Kristofer Lindenauer, Nishoni Huber, Zhi‐Hang Tao, Phat Luong, Stephen Rettie, ML Smith, Asim K. Bera, Alex Kang, Hannah Nguyen, Maika Schneider, , Joseph D. Mougous
The paper designs miniproteins that inhibit Bacteroides fragilis toxin by blocking receptor binding, preventing gut pathology without antibiotics.
bioRxiv · Jun 23, 2026 · PreprintMicrobiology