Author

Denise Chac

University of WashingtonORCID 0000-0002-4183-3899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ana A. WeiliD· 4 shared Susan M. MarkiewicziD· 3 shared Abigail G. SchindleriD· 1 shared Adam WaalkesiD· 1 shared Akhil KholwadwalaiD· 1 shared Alex KangiD· 1 shared Aline CuénodiD· 1 shared Alyssa Easton· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

Ana A. WeilORCID

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Author profile →

4 papers

Recent·Most cited

Orally available designed miniproteins inhibit enterotoxigenic Bacteroides fragilis pathology by blocking toxin receptor binding

Pooja Srinivas, Victor Adebomi, Susan M. Markiewicz, Kang Wang, Denise Chac, Kristofer Lindenauer, Nishoni Huber, Zhi‐Hang Tao, Phat Luong, Stephen Rettie, ML Smith, Asim K. Bera, Alex Kang, Hannah Nguyen, Maika Schneider, , Joseph D. Mougous

The paper designs miniproteins that inhibit Bacteroides fragilis toxin by blocking receptor binding, preventing gut pathology without antibiotics.

bioRxiv · Jun 23, 2026 · PreprintMicrobiology

If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice

Monica Tschang, Ronin Deo-Campo Vuong, Baylee Eilers, Denise Chac, Adam Waalkes, Kelsi M. Penewit, Alyssa Easton, Bryan P. Schuessler, Renata M. Daniels, Ana A. Weil, Stephen J. Salipante, Sean M. Gibbons, Abigail G. Schindler

This paper introduces a novel fecal microbiota transplant method using 'poopsicles' to reduce stress in mice, showing lower corticosterone levels and better microbial similarity compared to traditional gavage.

Frontiers in Immunology · Apr 24, 2026Peer-reviewedMicrobiology

Prevalent chromosome fusion in Vibrio cholerae O1

Aline Cuénod, Denise Chac, Ashraful Islam Khan, Fahima Chowdhury, Randy W. Hyppa, Susan M. Markiewicz, Amelia Rice, Akhil Kholwadwala, Stephen B. Calderwood, Edward Thomas Ryan, Jason B. Harris, Regina C. LaRocque, Taufiqur Rahman Bhuiyan, Gerald R. Smith, Firdausi Qadri, , B. Jesse Shapiro

The paper reports chromosome fusions in clinical V. cholerae O1 isolates, showing stable transmission between patients within a household.

Nature Communications · Jul 1, 2025Peer-reviewedMicrobiology

The Role of Morphological Adaptability in Vibrio cholerae's Motility and Pathogenicity

Jun Xu, Keigo Abe, Toshio Kodama, Marzia Sultana, Denise Chac, Susan M. Markiewicz, Hideyuki Matsunami, Erika Kuba, Shiyu Tsunoda, Munirul Alam, Ana A. Weil, Shuichi Nakamura, Tetsu Yamashiro

This study examines how morphological changes in Vibrio cholerae affect its motility and pathogenicity in different viscosity environments.

mBio · Nov 29, 2024Peer-reviewedMicrobiology