Victor Adebomi

Orally available designed miniproteins inhibit enterotoxigenic Bacteroides fragilis pathology by blocking toxin receptor binding

The paper designs miniproteins that inhibit Bacteroides fragilis toxin by blocking receptor binding, preventing gut pathology without antibiotics.

De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor

The paper designs high-affinity miniprotein binders targeting Flpp3, a virulence factor of Francisella tularensis, using physics-based and deep-learning methods, achieving sub-nanomolar affinities.

Accurate de novo design of high-affinity protein binding macrocycles using deep learning

This paper introduces RFpeptides, a deep learning framework for designing high-affinity macrocyclic peptides, achieving sub-nanomolar binding affinities and accurate structural predictions.