Upregulation of PD-L1 as a putative mechanism of resistance to CD47 inhibition in non-small cell lung cancer
Asa P. Y. Lau, Kristyna A. Gorospe, Kelsie L. Thu
This study shows that PD-L1 upregulation mediates resistance to CD47 inhibition in lung cancer, and dual inhibition of CD47 and PD-L1 improves survival in mouse models.
bioRxiv · Apr 28, 2026 · PreprintCancer Biology