Gut microbiota-derived indole-3 acetic acid mitigates key hallmarks of metabolic dysfunction-associated steatotic liver disease (MASLD) in an NLRP3-dependent manner in in vitro and diet-induced mouse models
Phulwanti Kumari Sharma, Lokesh Kumar, Akash Baghel, Pradipta Jana, Kritida Dhar, Ruby Bansal, Yamini Goswami, Anita Kumari, Rajni Yadav, S. Shalimar, Shailendra Asthana, Ruchi Tandon
This study identifies indole-3 acetic acid (I3A) as an NLRP3 inflammasome inhibitor that mitigates MASLD hallmarks in vitro and in diet-induced mouse models.
bioRxiv · Jan 27, 2026 · PreprintPharmacology & Toxicology