Pharmacology & ToxicologybioRxivPreprint
Gut microbiota-derived indole-3 acetic acid mitigates key hallmarks of metabolic dysfunction-associated steatotic liver disease (MASLD) in an NLRP3-dependent manner in in vitro and diet-induced mouse models
Phulwanti Kumari Sharma, Lokesh Kumar, Akash Baghel…·Ruchi Tandon
This study identifies indole-3 acetic acid (I3A) as an NLRP3 inflammasome inhibitor that mitigates MASLD hallmarks in vitro and in diet-induced mouse models.
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