Structural insights into Measles virus RNA synthesis: C protein-mediated regulation of replication-transcription switch and allosteric inhibition by ERDRP-0519
Tianjiao Du, Jiening Wang, Chengji Yang, Guobao Li, Kun Jie, Ying Chen, Xiaokang Zhang, Long Zhang, Gaojie Song, Qiansen Zhang, Shan Wu, Heng Ru
This study reveals how MeV C protein regulates RNA synthesis by stabilizing the RdRP complex and shows how ERDRP-0519 inhibits viral replication through an allosteric mechanism.
bioRxiv · Jul 21, 2025 · PreprintMicrobiology