LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates
Saskia Lesire, Rodrigo Lata, Yannick Hoogvliets, Kune Herrebosch, Paulien Van de Velde, Anouk Speleers, Frauke Christ, Siska Van Belle, Zeger Debyser
This study investigates the molecular interaction between MeCP2 and LEDGF, showing that the NID domain of MeCP2 binds to LEDGF's PWWP-CR1 region and that a RTT mutation disrupts this interaction.
bioRxiv · Apr 24, 2024 · PreprintMolecular Biology