Frauke Christ

This study investigates the molecular interaction between MeCP2 and LEDGF, showing that the NID domain of MeCP2 binds to LEDGF's PWWP-CR1 region and that a RTT mutation disrupts this interaction.

This study shows HIV integrase compacts viral DNA into biphasic condensates, with the core susceptible to inhibitors and the outer layer resistant.

The paper screens FDA-approved drugs and compounds to identify small molecules that rescue MeCP2-T158M speckle formation in NIH3T3 cells, finding HDAC inhibitors as effective rescuers.