Author

Rodrigo Lata

KU Leuven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Frauke ChristiD· 2 shared Zeger DebyseriD· 2 shared Anouk Speleers· 1 shared Hugo KlaasseniD· 1 shared Kune Herrebosch· 1 shared Liesbeth Steegmans· 1 shared Marnik NijsiD· 1 shared Matthias VerseleiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Frauke ChristORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates

Saskia Lesire, Rodrigo Lata, Yannick Hoogvliets, Kune Herrebosch, Paulien Van de Velde, Anouk Speleers, Frauke Christ, Siska Van Belle, Zeger Debyser

This study investigates the molecular interaction between MeCP2 and LEDGF, showing that the NID domain of MeCP2 binds to LEDGF's PWWP-CR1 region and that a RTT mutation disrupts this interaction.

bioRxiv · Apr 24, 2024 · PreprintMolecular Biology

HDAC inhibitors rescue MeCP2T158M speckles in a high content screen

Rodrigo Lata, Liesbeth Steegmans, Ranie Kellens, Marnik Nijs, Hugo Klaassen, Matthias Versele, Frauke Christ, Zeger Debyser

The paper screens FDA-approved drugs and compounds to identify small molecules that rescue MeCP2-T158M speckle formation in NIH3T3 cells, finding HDAC inhibitors as effective rescuers.

bioRxiv · Nov 2, 2023 · PreprintNeuroscience