CSF1R inhibitor levels determine sex-specific phenotype of resilient microglia and neurofunctional rescue leading to extended survival in tauopathy mice
Noah R. Johnson, Peng Yuan, Erika Castillo, T. Peter Lopez, Weizhou Yue, Annalise Bond, Brianna M. Rivera, Miranda C. Sullivan, Masakazu Hirouchi, Kurt Giles, Atsushi Aoyagi, Carlo Condello
The paper evaluates CSF1R inhibitors in tauopathy mice, finding sex-specific functional outcomes and suggesting sex-dependent effects on neuroprotection.
bioRxiv · Mar 20, 2021 · PreprintNeuroscience