Carlo Condello

The paper profiles NHD microglia and shows they adopt an antigen-presenting state without TREM2 dependence, triggering glial-to-neuronal changes.

The paper develops a spatial multi-omic method to study lipid dysregulation in Alzheimer's disease across brain regions in mice, identifying region-specific glial metabolic changes.

This study shows that targeting the PD-1/PD-L1 axis in glial cells improves microglial function and reduces neuronal hyperactivity in an Alzheimer's disease mouse model.

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

This study shows that β-amyloid induces microglial GPC4 and APOE, which increases neuronal tau pathology and toxicity.

The paper develops a high-throughput method to identify fluoroprobes that distinguish between tau fibril polymorphs using paDSF and chemical screening.

The paper identifies altered layer 1 astrocytes in schizophrenia using spatial and single-nucleus transcriptomics of the anterior cingulate cortex.

The paper uses cryo-EM to show that tau filaments in Down syndrome share the same structure as those in Alzheimer's disease.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

The paper introduces EMBER, a spectral imaging method using machine learning to identify amyloid strains in neurodegenerative diseases.

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

The paper evaluates CSF1R inhibitors in tauopathy mice, finding sex-specific functional outcomes and suggesting sex-dependent effects on neuroprotection.