The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells
Jason B. Williams, Shishir Mani Pant, Alexander L. Kley, Bharat Ashok Rajmalani, Clarence Yapp, Jiang Zhang, Kyle Deans, Elizabeth T. Rotrosen, Angelika Sales, Peter Karl Sorger, Thomas Seth Kupper
The paper identifies regulatory T cells suppressing tissue-resident CD8+ T cell programs in early melanoma, revealing a mechanism of immune evasion.
bioRxiv · Oct 21, 2025 · PreprintImmunology