Author

Thomas Seth Kupper

Brigham and Women's HospitalORCID 0000-0002-4229-2916Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexander L. KleyiD· 1 shared Alexandru M. PleşaiD· 1 shared Andrew L. JiiD· 1 shared Angelika SalesiD· 1 shared Anna MandinovaiD· 1 shared Asaf Ashkenazy-Titelman· 1 shared Bharat Ashok RajmalaniiD· 1 shared Clarence YappiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Alexander L. KleyORCID

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2 papers

Recent·Most cited

Human skin rejuvenation via mRNA

Li Li, Zhengkuan Tang, Xavier Portillo, Rohit Arora, Madeleine Yang, Esther Mintzer, Zhenrui Zhang, Stefano Sol, Fabiana Boncimino, Patrick Han, Michelle Z. Dion, Emery Di Cicco, D.D. Majewski, Asaf Ashkenazy-Titelman, Alexandru M. Pleşa, , George McDonald Church

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

Journal of Investigative Dermatology · Jul 21, 2026Peer-reviewedSynthetic Biology

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells

Jason B. Williams, Shishir Mani Pant, Alexander L. Kley, Bharat Ashok Rajmalani, Clarence Yapp, Jiang Zhang, Kyle Deans, Elizabeth T. Rotrosen, Angelika Sales, Peter Karl Sorger, Thomas Seth Kupper

The paper identifies regulatory T cells suppressing tissue-resident CD8+ T cell programs in early melanoma, revealing a mechanism of immune evasion.

bioRxiv · Oct 21, 2025 · PreprintImmunology