A conserved dimerization element is required for protein kinase activation by trans-autophosphorylation
Samuel Botterbusch, Vienna L. Huso, Kyler A. Weingartner, Grétar Tryggvason, Katherine W. Tripp, Rachel Green, Jennifer M. Kavran
This study identifies a conserved helix (G) mediating dimerization during trans-autophosphorylation in kinases across species, showing it is required for activation despite structural diversity.
bioRxiv · May 25, 2026 · PreprintBiochemistry