Symmetry breaking of hPSCs in micropattern generates a polarized spinal cord-like organoid (pSCO) with dorsoventral organization
Kyubin Seo, Subin Cho, Hyogeun Shin, Aeri Shin, Ju‐Hyun Lee, June Hoan Kim, Boram Lee, Hwanseok Jang, Young‐Ju Kim, Hyo Min Cho, Yongdoo Park, Hee Youn Kim, Taeseob Lee, Woong‐Yang Park, Yong Jun Kim, , Woong Sun
This study generates a polarized spinal cord-like organoid with dorsoventral organization using geometrically confined hPSC cultures and shows that BMP and Shh signaling control DV patterning.
Advanced Science · May 12, 2023Peer-reviewedDevelopmental Biology