Woong‐Yang Park

HARP integrates PBMC data from multiple studies to create a reference atlas with consensus annotations and identifies age, sex, and disease-related cellular modules.

This paper develops a multi-epitope mRNA/LNP vaccine using AI-prioritized neoantigens, showing enhanced immunogenicity and antitumor activity in preclinical models.

The paper identifies a transitional CAF-like fibroblast state associated with FOXF1/FOXF2 across multiple cancers using single-cell transcriptomics and spatial data.

STRUMP-I improves pMHC-I binding prediction by using force-field energy features, outperforming sequence-based methods on underrepresented MHC alleles and showing synergy with them.

The paper examines the relationship between clonal hematopoiesis burden and immune response in NSCLC patients, finding higher CHIP prevalence in cancer patients and inflammatory pathway enrichment in myeloid cells with severe CHIP.

The paper identifies a CD8+ T cell effector signature linked to lung cancer immunotherapy prognosis using single-cell RNA sequencing and eQTL analysis.

The paper presents AIDA, a diverse single-cell RNA-seq atlas of immune cells, revealing sub-continental diversity impacts on immune cell properties and identifying functional genetic variants.

Transplanting human hypothalamic neural stem cells into aged mice improves metabolic, physical, and cognitive function via the SNS/eNAMPT axis.

TSpred is a deep learning framework for predicting TCR-epitope interactions using paired chain TCR data, achieving state-of-the-art performance in both seen and unseen epitope predictions.

The paper introduces scLinaX, a method to quantify X chromosome inactivation escape using scRNA-seq, revealing heterogeneity across cell types and tissues.

This study generates a polarized spinal cord-like organoid with dorsoventral organization using geometrically confined hPSC cultures and shows that BMP and Shh signaling control DV patterning.

Monopogen calls single nucleotide variants from single-cell sequencing data, achieving high accuracy in germline variant detection and enabling ancestry inference and variant association analysis.

This study performs a GWAS on creativity using 241,736 individuals, identifying 25 loci and showing genetic overlap with several psychiatric disorders.

This study identifies TMEM43 mutations as a cause of autosomal dominant auditory neuropathy spectrum disorder by showing their interaction with Connexin-mediated channels in cochlear glia-like supporting cells.

JuLI improves DNA fusion detection in clinical sequencing by reducing false positives and increasing sensitivity, outperforming existing methods in high-depth sequencing.

This paper introduces PHLI-seq, a method to isolate and sequence cancer cells in 3D space, revealing genomic heterogeneity and linking genotypes to phenotypes in breast cancer.