Bridging in vitro and in vivo insights: A PKPD model for effective phage therapy against multidrug-resistant Pseudomonas aeruginosa
Jun Seok Cha, Kyungnam Kim, Hwa Jeong You, Dasom Kim, Hyun Hee Park, Su‐Jin Heo, Choon Ok Kim, Byung Hak Jin, Dongeun Yong, Dongwoo Chae
This study develops a PKPD model integrating in vitro and in vivo data to optimize phage therapy against multidrug-resistant Pseudomonas aeruginosa, showing that phage combinations delay resistance but may lead to immune clearance of resistant mutants.
mSystems · Nov 13, 2025Peer-reviewedMicrobiology