Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation
A. S. Nam, N. Dusaj, F. Izzo, R. Murali, R. M. Myers, T. Mouhieddine, J. Sotelo, S. Benbarche, M. Waarts, F. Gaiti, S. Tahri, R. Levine, O. Abdel-Wahab, L. A. Godley, R. Chaligne, , D. Landau
This study uses single-cell multi-omics to show DNMT3A R882 mutations cause hypomethylation and alter progenitor cell fates in clonal hematopoiesis.
bioRxiv · Jan 14, 2022 · PreprintCancer Biology