R. Murali

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

Metabolic evolution of pyranopterin-dependent biochemistry

The paper models metabolic evolution and finds that Mo-dependent biochemistry emerged after oxygen rise, supported by genomic and machine learning analyses.

An evolutionary timescale for Bacteria calibrated using the Great Oxidation Event

This paper uses machine learning and phylogenetic reconciliation to estimate the evolutionary timeline of Bacteria, linking transitions to aerobic lifestyles to the Great Oxidation Event.

The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2

This study shows the homeodomain stabilizes ONECUT2-DNA binding through allosteric modulation and conserved base interactions, with implications for prostate cancer.

Cancer cells co-evolve with retrotransposons to mitigate viral mimicry

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

Physiological adaptation of sulfate reducing bacteria in syntrophic partnership with anaerobic methanotrophic archaea

This study examines the metabolic adaptations of sulfate-reducing bacteria in syntrophic partnerships with methanotrophic archaea, revealing unique evolutionary changes in protein pathways.

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

This study uses single-cell multi-omics to show DNMT3A R882 mutations cause hypomethylation and alter progenitor cell fates in clonal hematopoiesis.

Diversity and evolution of nitric oxide reduction

This study identifies new nitric oxide reductase families and shows they evolved independently from oxygen reductases, expanding known denitrifying microbes.

Evolution of the cytochrome-bd type oxygen reductase superfamily and the function of cydAA in Archaea

This study identifies three families of cytochrome bd-type oxygen reductases, showing that only one uses quinol as an electron donor, and demonstrates that CydAA from Archaea uses quinol and only b-type hemes.

RIPK2 Stabilizes c-Myc and is an Actionable Target for Inhibiting Prostate Cancer Metastasis

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

Structural studies of the Tudor domain from the Bombyx homolog of Drosophila PAPI: Implication to piRNA biogenesis

The paper presents crystal structures of the Tudor domain of BmPAPI to understand its role in piRNA processing.

Targeting the Id1-Kif11-Aurka axis in triple negative breast cancer using combination therapy

This paper investigates how Id1 and Id3 maintain chemoresistant CSCs in TNBC by targeting Kif11 and Aurka, and explores combination therapy to enhance tumor debulking.