R. M. Myers

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

This study uses single-cell multi-omics to show DNMT3A R882 mutations cause hypomethylation and alter progenitor cell fates in clonal hematopoiesis.

The paper analyzes single-cell data from CAR T infusion products to identify factors associated with CD19-positive relapse in ALL patients.

The paper identifies recurrent genomic loci involved in stickleback adaptation to freshwater habitats and shows they predict evolutionary changes in Darwin's finches.

The paper assembles a young Y chromosome from threespine stickleback, revealing convergent evolutionary features with older sex chromosomes.

This study identifies GR and STAT3 as cooperative drivers of basal-like triple negative breast cancer gene expression and shows that their inhibition synergistically reduces cell proliferation.

The paper introduces a model-based method to analyze T cell receptor repertoire clone size distributions and applies it to datasets to identify differences across biological conditions.