Safety, pharmacokinetics, and liver-stage Plasmodium cynomolgi effect of high-dose ivermectin and chloroquine in Rhesus Macaques
P. Vanachayangkul, R. Im-Erbsin, A. Tungtaeng, C. Kodchakorn, A. Roth, J. H. Adams, C. Chaisatit, P. Saingam, R. J. Sciotti, G. A. Reichard, C. K. Nolan, B. S. Pybus, C. C. Black, L. A. Lugo, M. D. Wegner, , K. C. Kobylinski
This study evaluates the safety, pharmacokinetics, and efficacy of high-dose ivermectin and chloroquine in Rhesus macaques against Plasmodium cynomolgi liver stages, finding no inhibition of blood-stage parasitemia but good tolerability.
bioRxiv · Apr 27, 2020 · PreprintPharmacology & Toxicology