Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase
L. Abbouche, V. J. Murphy, J. Gao, S. van Twest, A. P. Sobinoff, K. M. Auweiller, H. A. Pickett, R. Bythell-Douglas, A. J. Deans
This study identifies the Hel2i domain as essential for FANCM's DNA binding and branch migration, revealing its role in suppressing the ALT pathway in cancer cells.
bioRxiv · May 23, 2024Biochemistry