Author

S. van Twest

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:genome assembly· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

A. J. Deans· 2 shared V. J. Murphy· 2 shared A. Leis· 1 shared C. Hodson· 1 shared E. Dunn· 1 shared J. J. O'Rourke· 1 shared M. Sharp· 1 shared M. W. Parker· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. J. Deans

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2 papers

Recent·Most cited

Monoubiquitination by the Fanconi Anemia core complex locks FANCI:FANCD2 on DNA in filamentous arrays

W. Tan, S. van Twest, A. Leis, R. Bythell-Douglas, V. J. Murphy, M. Sharp, M. W. Parker, W. M. Crismani, A. J. Deans

This study shows that monoubiquitination of FANCD2 stabilizes the FANCI:FANCD2 complex on DNA and forms filamentous arrays, revealing a mechanism for DNA repair pathway activation.

bioRxiv · Dec 3, 2019Biochemistry

FANCM-family branchpoint translocases remove co-transcriptional R-loops

C. Hodson, J. J. O'Rourke, S. van Twest, V. J. Murphy, E. Dunn, A. J. Deans

This study shows FANCM and its orthologs unwind co-transcriptional R-loops, preventing genome instability, and identifies their conserved role across species.

bioRxiv · Jan 15, 2018Biochemistry