Threshold inclusion size triggers conversion of huntingtin to prion-like state that is reversible in newly born cells
L. Asgarkhani, I. Khandakar, R. Pakan, T. C. Swayne, L. Emtage
The paper shows that a threshold inclusion size in yeast cells triggers a prion-like conversion of mutant Huntingtin, which is reversible in newly born cells.
bioRxiv · Feb 13, 2023 · PreprintCell Biology