Cancer BiologybioRxiv
BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor
W. C. Fiskus, J. Piel, M. Collins…·K. N. Bhalla
This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.
DOI 10.1182/blood.2023022832