This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

bioRxiv · Sep 28, 2023Cancer Biology

Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

V. Vollenweider, K. Rehm, C. Chepkirui, M. Perez-Berlanga, M. Polymenidou, J. Piel, L. Bigler, R. Kuemmerli

This study identifies pyoverdines from Pseudomonas spp. as potent antibacterials against human pathogens by inducing iron starvation, showing reduced resistance potential compared to antibiotics.

bioRxiv · Jul 18, 2023Microbiology

Integration host factor regulates colonization factors in the bee gut symbiont Frischella perrara

K. Schmidt, G. Santos-Matos, S. Leopold-Messer, Y. El Chazli, O. Emery, T. Steiner, J. Piel, P. Engel

This study identifies IHF as a regulator of colonization factors in the bee gut symbiont F. perrara, showing its role in metabolite production and gut colonization.

bioRxiv · Dec 6, 2021Microbiology

Single-cell metabolite detection and genomics reveals uncultivated talented producer

M. Kogawa, R. Miyaoka, F. Hemmerling, M. Ando, K. Yura, K. Ide, Y. Nishikawa, M. Hosokawa, Y. Ise, J. K. B. Cahn, K. Takada, S. Matsunaga, T. Mori, J. Piel, H. Takeyama

This study identifies an uncultivated bacterium as a producer of antifungal metabolites using Raman microscopy and single-cell sequencing in a sponge microbiome.

bioRxiv · Sep 11, 2021Microbiology

Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

E. Bakkeren, J. A. Herter, J. S. Huisman, Y. Steiger, E. Gul, J. P. M. Newson, A. O. Brachmann, J. Piel, R. R. Regoes, S. Bonhoeffer, M. Diard, W.-D. Hardt

This study shows that plasmid dissemination in the gut is enhanced by antibiotic degradation in the lumen and cycling between gut and tissue reservoirs in Salmonella Typhimurium.

bioRxiv · Apr 8, 2021Evolutionary Biology

Uncharted biosynthetic potential of the ocean microbiome

L. Paoli, H.-J. Ruscheweyh, C. C. Forneris, S. Kautsar, Q. Clayssen, G. Salazar, A. Milanese, D. Gehrig, M. Larralde, L. Carroll, P. Sanchez, A. A. Zayed, D. R. Cronin, S. G. Acinas, P. Bork, , S. Sunagawa

This study identifies over 40,000 putative biosynthetic gene clusters in ocean microbes, revealing novel biosynthetic potential and a new candidate genus with diverse metabolic capabilities.

bioRxiv · Mar 24, 2021Microbiology

Identification of trans-AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors

D. Kacar, L. M. Canedo, P. Rodriguez, E. Gonzalez, B. Galan, C. Schleissner, S. Leopold-Messer, J. Piel, C. Cuevas, F. de la Calle, J. L. Garcia

This paper identifies trans-AT polyketide gene clusters in two marine bacteria, revealing evolutionary relationships between sesbanimides, glutaramides, and pederin-like pathways.

bioRxiv · Sep 18, 2020Microbiology

Snf2 controls pulcherriminic acid biosynthesis and connects pigmentation and antifungal activity of the yeast Metschnikowia pulcherrima

D. Gore-Lloyd, I. Sumann, A. O. Brachmann, K. Schneeberger, R. A. Ortiz-Merino, M. Moreno-Beltran, M. Schlaefli, P. Kirner, A. Santos Kron, K. H. Wolfe, J. Piel, C. H. Ahrens, D. Henk, F. M. Freimoser

This paper identifies SNF2 as a regulator of antifungal activity and pulcherriminic acid biosynthesis in Metschnikowia pulcherrima by comparing a wildtype strain with a pigmentless mutant.

bioRxiv · Dec 13, 2018 · PreprintMicrobiology

\"In plaque-mass spectrometry imaging\" reveals a major metabolic shift towards odd-chain fatty acid lipids induced by host-virus interactions

G. Schleyer, N. Shahaf, C. Ziv, Y. Dong, R. A. Meoded, E. J. N. Helfrich, D. Schatz, S. Rosenwasser, I. Rogachev, A. Aharoni, J. Piel, A. Vardi

The paper uses plaque-MSI to reveal a metabolic shift towards odd-chain fatty acid lipids during host-virus interactions in Emiliania huxleyi.

bioRxiv · May 8, 2018Microbiology