Paracoccidioides HSP90 can be found in the cell surface and is a target for antibodies with therapeutic potential
A. N. D. Moura, D. S. L. d. Oliveira, V. Paredes, L. B. Rocha, A. Casadevall, P. Albuquerque, M. S. S. Felipe, R. M. F. Piazza, A. M. Nicola
The paper generates a monoclonal antibody against HSP90 in Paracoccidioides fungi that opsonizes fungal cells and enhances macrophage uptake, suggesting potential for immunotherapy.
bioRxiv · Jul 29, 2020Microbiology