V. Paredes

Hinge Influences in Murine IgG Binding to Cryptococcus neoformans Capsule

This paper investigates how the constant region, specifically the hinge, influences antigen binding in murine IgG antibodies targeting Cryptococcus neoformans capsule polysaccharides, showing that the hinge is necessary but not sufficient for binding differences between isotypes.

Paracoccidioides HSP90 can be found in the cell surface and is a target for antibodies with therapeutic potential

The paper generates a monoclonal antibody against HSP90 in Paracoccidioides fungi that opsonizes fungal cells and enhances macrophage uptake, suggesting potential for immunotherapy.