Activity-dependent COX-2 proteolysis generates a catalytically inactive fragment that affects aerobic respiration and proliferation
L. H. Hartal-Benishay, S. Tal, A. Abd Elkader, O. Ehsainieh, R. Sroji-Eid, M. Mikl, L. Barki-Harrington
The paper shows that COX-2 proteolysis generates catalytically inactive fragments that affect mitochondrial function and cell proliferation in colon tumors.
bioRxiv · Apr 8, 2024 · PreprintCell Biology