The Pharmacodynamic-Toxicodynamic Relationship of AUC and CMAX in Vancomycin Induced Kidney Injury in an Animal Model
S. Avedissian, G. Pais, J. Liu, J. N. O'Donnell, T. Lodise, M. Neely, W. Prozialeck, P. Lamar, L. Becher, M. H. Scheetz
This study investigates the pharmacodynamic-toxicodynamic relationship of vancomycin-induced kidney injury in rats, finding that peak concentrations and fewer daily doses correlate with increased kidney injury.
bioRxiv · Aug 27, 2020Pharmacology & Toxicology