Activation of a Protein Kinase Via Asymmetric Allosteric Coupling of Structurally Conserved Signaling Modules
Y. Hao, J. P. England, L. Belluci, E. Paci, H. C. Hodges, S. S. Taylor, R. A. Maillard
The paper investigates how cAMP binding regulates PKA through asymmetric allosteric coupling, identifying a new cAMP-responsive switch that acts as a signaling hub.
bioRxiv · Apr 18, 2019 · PreprintBiophysics