S. S. Taylor

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

This study identifies the αC-β4 loop as a key regulator of allosteric cooperativity between nucleotide and substrate in PKA-C through simulations and mutagenesis experiments.

Molecular Determinants and Signaling Effects of PKA RIα Phase Separation

This study identifies molecular determinants of PKA RIα phase separation and shows how it regulates cAMP compartmentation and PKA-C spatial restriction.

Capturing differences in the regulation of LRRK2 dynamics and conformational states by small molecule kinase inhibitors

This study uses simulations and HDX-MS to analyze how two LRRK2 inhibitors affect the protein's conformational dynamics and kinase activity.

Comparing multiscale, presence-only habitat suitability models created with structured survey data and community science data for a rare warbler species at the southern range margin

This study compares habitat suitability models for Golden-winged Warblers using structured survey data and community science data, finding similar performance and identifying road density as a key landscape variable.

Molecular-Dynamics Simulation Methods for Macromolecular Crystallography

The paper applies molecular-dynamics simulations to macromolecular crystallography to refine protein structures and improve interpretation of electron density.

Two helices control the dynamic crosstalk between the catalytic domains of LRRK2

The paper identifies two helices that regulate the conformation and function of the kinase domain in LRRK2 through dynamic crosstalk.

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction

This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.

Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition

SCA14 driver mutations in PKCγ impair autoinhibition, with defect correlating inversely with age of disease onset.

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

Classification of ovarian cancer cell lines using transcriptional profiles defines the five major pathological subtypes

This paper classifies ovarian cancer cell lines into five subtypes using transcriptional profiles, aligning with known pathological subtypes and providing a method for future classification.

Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2

This study investigates how Parkinson's Disease mutations affect LRRK2 activation and subcellular localization through conformational changes and domain interactions.

Inhibitors of the Bub1 spindle assembly checkpoint kinase: Synthesis of BAY-320 and comparison with 2OH-BNPP1

This study compares two Bub1 kinase inhibitors, finding that BAY-320 inhibits Bub1 in vivo but with high concentrations and potential off-target effects, while 2OH-BNPP1 is ineffective.

Activation of a Protein Kinase Via Asymmetric Allosteric Coupling of Structurally Conserved Signaling Modules

The paper investigates how cAMP binding regulates PKA through asymmetric allosteric coupling, identifying a new cAMP-responsive switch that acts as a signaling hub.