Pharmacology & ToxicologybioRxiv
Acquired and intrinsic resistance to vemurafenib in BRAFV600E-driven melanoma brain metastases
P. Zhang, L. E. Kuil, L. C. M. Buil…·M. C. de Gooijer
This study shows that BRAFV600E-driven melanoma brain metastases are intrinsically protected from vemurafenib by the blood-brain barrier and can rapidly acquire resistance through non-canonical signaling.
DOI 10.1002/2211-5463.13730