Author

O. van Tellingen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

L. Wang· 2 shared M. C. de Gooijer· 2 shared R. Bernards· 2 shared A. B. Smit· 1 shared A. Compter· 1 shared A. Jurgens· 1 shared A. Martinez-Marti· 1 shared A. Schepers· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

L. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Acquired and intrinsic resistance to vemurafenib in BRAFV600E-driven melanoma brain metastases

P. Zhang, L. E. Kuil, L. C. M. Buil, S. Freriks, J. H. Beijnen, O. van Tellingen, M. C. de Gooijer

This study shows that BRAFV600E-driven melanoma brain metastases are intrinsically protected from vemurafenib by the blood-brain barrier and can rapidly acquire resistance through non-canonical signaling.

bioRxiv · Dec 20, 2022Pharmacology & Toxicology

Fractionated brain irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior and cognition in mice

L. Kuil, R. Seigers, M. Loos, M. C. de Gooijer, A. Compter, W. Boogerd, O. van Tellingen, A. B. Smit, S. B. Schagen

This study shows that fractionated brain irradiation reduces hippocampal immature neurons in mice but does not affect spontaneous behavior or traditional cognitive tasks.

bioRxiv · Sep 1, 2022 · PreprintAnimal Behavior & Cognition

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Z. Pogacar, J. L. Johnson, L. Krenning, G. De Conti, C. Lieftink, A. Velds, L. Wardak, F. Jochems, K. Groot, A. Schepers, L. Wang, J.-Y. Song, M. van de Ven, O. van Tellingen, R. H. Medema, , R. Leite de Oliveira

The paper identifies that combining indisulam with palbociclib enhances senescence in cancer cells by inhibiting CDK2 kinase activity.

bioRxiv · Oct 18, 2021Cancer Biology

Reanalysis of in vivo drug synergy validation study rules out synergy in most cases

O. van Tellingen, R. de Menezes

This paper reanalyzes an in vivo drug synergy study and finds that most drug pairs do not show statistically significant synergy when using appropriate statistical methods.

bioRxiv · Nov 13, 2020Pharmacology & Toxicology

Multiple Low Dose therapy: an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

J. M. Fernandes Neto, E. Nadal, S. N. Ooft, E. Bosdriesz, L. Farre, C. McLean, S. Klarenbeek, A. Jurgens, H. Hagen, L. Wang, E. Felip, A. Martinez-Marti, E. Voest, L. Wessels, O. van Tellingen, , R. Bernards

This paper shows that using multiple low doses of drugs targeting different components of a signaling pathway can effectively treat EGFR inhibitor-resistant NSCLC without resistance development.

bioRxiv · Oct 29, 2019Cancer Biology