L. Chou-Zheng

This study identifies RNase R as a third nuclease essential for Type III CRISPR-Cas immunity, working with PNPase to mature crRNAs and eliminate invading nucleic acids.

This study identifies a single multifunctional enzyme, Nhi, that provides robust nucleic acid immunity against phages by acting as both sensor and effector.

This study shows that a Type III-A CRISPR-Cas system in Staphylococcus epidermidis uses PNPase and RNase J2 degradosome nucleases for crRNA maturation and phage defense.