Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide
S. Santamaria, D. Cuffaro, E. Nuti, L. Ciccone, T. Tuccinardi, F. Liva, F. D'Andrea, R. de Groot, A. Rossello, J. Ahnstroem
This study identifies an exosite on ADAMTS-5 as a target for selective inhibitors, demonstrating that binding to this site improves selectivity over active site targeting.
bioRxiv · Jun 12, 2020 · PreprintBiochemistry