Author

R. de Groot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:flow cytometry· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Guislain· 3 shared K. Monkhorst· 3 shared A. J. Katan· 2 shared C. Dekker· 2 shared J.-K. Ryu· 2 shared K. J. Hartemink· 2 shared M. C. Wolkers· 2 shared S. M. Castenmiller· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

A. Guislain

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tertiary lymphoid structure-related immune infiltrates in NSCLC tumor lesions correlate with low tumor-reactivity of TIL products

S. M. Castenmiller, N. Kanagasabesan, A. Guislain, B. Nicolet, M. van Loenen, K. Monkhorst, A. Veenhof, E. Smit, K. Hartemink, J. Haanen, R. de Groot, M. Wolkers

This study identifies that high B cell infiltrates in NSCLC tumors, associated with tertiary lymphoid structures, negatively correlate with the tumor-reactivity of expanded TIL products.

bioRxiv · Feb 19, 2024Immunology

Effective generation of tumor-infiltrating lymphocyte products from metastatic non-small-cell lung cancer (NSCLC) lesions irrespective of location and previous treatments.

S. M. Castenmiller, R. de Groot, A. Guislain, K. Monkhorst, K. J. Hartemink, A. A. F. A. Veenhof, E. F. Smit, J. B. A. G. Haanen, M. C. Wolkers

This study shows that tumor-infiltrating lymphocytes (TILs) can be effectively generated from metastatic NSCLC lesions regardless of location or prior treatments, with 76% showing anti-tumoral activity.

bioRxiv · Jan 28, 2022Cancer Biology

Phase separation induced by cohesin SMC protein complexes

J.-K. Ryu, C. Bouchoux, H. W. Liu, E. Kim, M. Minamino, R. de Groot, A. J. Katan, A. Bonato, D. Marenduzzo, D. Michieletto, F. Uhlmann, C. Dekker

Yeast cohesin phase separates with DNA into liquid droplets via ATP-independent DNA bridging.

bioRxiv · Jun 13, 2020Biophysics

Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide

S. Santamaria, D. Cuffaro, E. Nuti, L. Ciccone, T. Tuccinardi, F. Liva, F. D'Andrea, R. de Groot, A. Rossello, J. Ahnstroem

This study identifies an exosite on ADAMTS-5 as a target for selective inhibitors, demonstrating that binding to this site improves selectivity over active site targeting.

bioRxiv · Jun 12, 2020 · PreprintBiochemistry

AFM images of open and collapsed states of yeast condensin suggest a scrunching model for DNA loop extrusion

J.-K. Ryu, A. J. Katan, E. O. van der Sluis, T. Wisse, R. de Groot, C. Hearing, C. Dekker

The paper uses AFM to visualize yeast condensin and its DNA interactions, suggesting a scrunching model for DNA loop extrusion.

bioRxiv · Dec 13, 2019 · PreprintBiophysics

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

R. de Groot, M. M. van Loenen, A. Guislain, B. P. Nicolet, J. J. Freen-van Heeren, O. Verhagen, M. M. van den Heuvel, J. de Jong, P. Burger, E. van der Schoot, R. M. Spaapen, D. Amsen, J. B. Haanen, K. Monkhorst, K. J. Hartemink, M. C. Wolkers

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

bioRxiv · Jun 8, 2019Immunology