Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3
D. M. Calcagno, R. Ng, A. Toomu, C. Zhang, K. Huang, A. Aguirre, R. Weissleder, L. Daniels, Z. Fu, K. King
The paper shows type I interferon responses to ischemic injury start in the bone marrow of mice and humans, involving Tet2, Nrf2, and Irf3, and identifies ISG scores as a clinical biomarker.
bioRxiv · Jan 3, 2020 · PreprintImmunology