A. Aguirre

Dynamics of Collagen Oxidation and Cross Linking in Regenerating and Irreversibly Infarcted Myocardium

The paper develops fluorescent probes to study collagen oxidation and cross-linking in mouse and zebrafish myocardium, finding that mature cross-links form in mouse scars but not in zebrafish, potentially enabling regeneration.

ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes

This study uses human heart organoids to show that pregestational diabetes causes ER stress and lipid imbalance, leading to cardiomyopathy, and identifies potential therapeutic targets.

Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation

This study reveals the scaffold-client model of PRC1 condensate assembly through phase separation, showing how CBX2 acts as a scaffold and other subunits influence condensate properties and composition.

A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

This paper develops a patterned human heart tube organoid model using pluripotent stem cell self-assembly, showing anterior-posterior patterning and multiple cardiac cell types.

Cancer tissue of origin constrains the growth and metabolism of metastases

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

Longitudinal Morphological and Functional Characterization of Human Heart Organoids Using Optical Coherence Tomography

This study uses optical coherence tomography to track the morphological and functional development of human heart organoids over time.

Serological Profile Of Specific Antibodies Against Dominant Antigens Of SARS-CoV-2 In Chilean COVID-19 Patients.

The paper evaluates antibody responses against SARS-CoV-2 Spike and Nucleocapsid proteins in Chilean COVID-19 patients using western blot and ELISA, finding higher frequency of anti-N antibodies and comparable sensitivity and specificity between antigens.

Lactate promotes cardiomyocyte dedifferentiation through metabolic reprogramming

This study shows lactate induces dedifferentiation in cardiomyocytes by metabolic reprogramming, enhancing proliferation and supporting cardiac regeneration.

GENERATION OF HEART ORGANOIDS MODELING EARLY HUMAN CARDIAC DEVELOPMENT UNDER DEFINED CONDITIONS

This paper develops a scalable, high-fidelity in vitro model of human cardiac development using hPSCs, showing high similarity to fetal hearts in morphology and cell-type complexity.

Type I interferon responses to ischemic injury begin in the bone marrow of mice and humans and depend on Tet2, Nrf2, and Irf3

The paper shows type I interferon responses to ischemic injury start in the bone marrow of mice and humans, involving Tet2, Nrf2, and Irf3, and identifies ISG scores as a clinical biomarker.

Ingested insecticide to control Aedes aegypti: Developing a novel dried attractive toxic sugar bait device for intra-domiciliary control

This study develops and tests a novel dried attractive toxic sugar bait device to kill Aedes aegypti mosquitoes, showing high lethality in both lab and semi-field settings.