ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas
L. Darmusey, G. Perot, N. Thebault, S. Le Guellec, N. Desplat, L. Gaston, L. Delespaul, T. Lesluyes, E. Darbo, A. Gomez-Brouchet, E. Richard, J. Baud, L. Leroy, J. M. Coindre, J.-Y. Blay, F. Chibon
This study shows ATRX mutations in sarcomas promote tumor growth and immune escape by reducing mast cell immunity, suggesting targeting the innate immune system could improve outcomes.
bioRxiv · Oct 23, 2020Cancer Biology