Author

T. Lesluyes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Assay:whole-genome sequencing· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2

Frequent Co-Authors

P. Van Loo· 3 shared A. Abbasi· 1 shared A. Gomez-Brouchet· 1 shared A. Khandekar· 1 shared A. L. K. Tan· 1 shared A. M. Flanagan· 1 shared A. S. M. Islam· 1 shared C. D. Steele· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

P. Van Loo

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Author profile →

4 papers

Recent·Most cited

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

K. K. Huang, H. Ma, T. Uchihara, T. Sheng, R. H. H. Chong, F. Zhu, S. Srivastava, S. T. Tay, R. Sundar, A. L. K. Tan, X. Ong, M. Lee, S. W. T. Ho, T. Lesluyes, P. Van Loo, , P. Tan

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

bioRxiv · Apr 10, 2023Cancer Biology

Signatures of copy number alterations in human cancer

C. D. Steele, A. Abbasi, A. S. M. Islam, A. Khandekar, K. Haase, S. Hames, M. Tarabichi, T. Lesluyes, A. M. Flanagan, F. Mertens, P. Van Loo, L. B. Alexandrov, N. Pillay

This paper identifies 19 copy number signatures in 9,873 cancers, explaining 93% of TCGA samples, and reveals diverse mechanisms underlying copy number alterations in human cancer.

bioRxiv · Apr 30, 2021Cancer Biology

ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas

L. Darmusey, G. Perot, N. Thebault, S. Le Guellec, N. Desplat, L. Gaston, L. Delespaul, T. Lesluyes, E. Darbo, A. Gomez-Brouchet, E. Richard, J. Baud, L. Leroy, J. M. Coindre, J.-Y. Blay, F. Chibon

This study shows ATRX mutations in sarcomas promote tumor growth and immune escape by reducing mast cell immunity, suggesting targeting the innate immune system could improve outcomes.

bioRxiv · Oct 23, 2020Cancer Biology

An Integrative Analysis of the Age-Associated Genomic, Transcriptomic and Epigenetic Landscape across Cancers

K. Chatsirisupachai, T. Lesluyes, L. Paraoan, P. Van Loo, J. P. de Magalhaes

This study analyzes age-related genomic, transcriptomic, and epigenetic changes across cancers using TCGA data, finding increased genomic instability and mutations in older patients.

bioRxiv · Aug 25, 2020Cancer Biology