Author

L. Di

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:variant calling· 2 Organism:virus· 2

Frequent Co-Authors

S. Akther· 5 shared W. Qiu· 5 shared L. Li· 4 shared B. Sulkow· 3 shared E. Bezrucenkovas· 3 shared A. Larracuente· 1 shared B. J. Luft· 1 shared B. M. Zeglis· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

S. Akther

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Development of recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens

L. Li, L. Di, S. Akther, B. M. Zeglis, W. Qiu

This study develops recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens, showing they react strongly with human and rabbit sera and are promising for diagnostics and therapeutics.

bioRxiv · May 5, 2022 · PreprintMicrobiology

Following the Trail of One Million Genomes: Footprints of SARS-CoV-2 Adaptation to Humans

S. Akther, E. Bezrucenkovas, L. Li, B. Sulkow, L. Di, D. Pante, C. L. Martin, B. J. Luft, W. Qiu

This study analyzes one million SARS-CoV-2 genomes to identify human-adaptive mutations and develop a simulator to predict viral evolution under different models.

bioRxiv · May 7, 2021 · PreprintEvolutionary Biology

Maximum Antigen Diversification in a Lyme Bacterial Population and Evolutionary Strategies to Overcome Pathogen Diversity

L. Di, S. Akther, E. Bezrucenkovas, L. Ivanova, B. Sulkow, B. Wu, M. Gomes-Solecki, W. Qiu

The paper shows evolution-based synthetic antigen designs can overcome pathogen diversity by generating broadly reactive OspC analogs against Lyme disease strains.

bioRxiv · Dec 16, 2020Microbiology

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

M. Cheng, Z. Cheng, Y. Yu, W. Liu, R. Li, Z. Guo, J. Qin, Z. Zeng, L. Di, Y. Mo, C. Pan, Y. Liang, J. Li, Y.-G. Tong, Y. Yan, , K. Ning

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

bioRxiv · Sep 15, 2020 · PreprintBioengineering

CoV Genome Tracker: tracing genomic footprints of Covid-19 pandemic

S. Akther, E. Bezrucenkovas, B. Sulkow, C. Panlasigui, L. Li, W. Qiu, L. Di

CoV Genome Tracker tracks SARS-CoV-2 genomic changes using haplotype networks and provides evolutionary rates to support pandemic response.

bioRxiv · Apr 10, 2020 · PreprintEvolutionary Biology

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C (ospC) amplicons

L. Di, Z. Wan, S. Akther, C. Ying, A. Larracuente, L. Li, C. Di, R. Nunez, D. M. Cucura, N. L. Goddard, K. Krampis, W. Qiu

The paper develops a deep sequencing method to identify and quantify Lyme pathogen strains by analyzing the ospC gene in ticks, revealing mixed infections and a new strain related to Borreliella bissettiae.

bioRxiv · Jun 4, 2018Microbiology