Author

Y.-G. Tong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:metagenomics· 2 Organism:rat· 2

Frequent Co-Authors

H. Fan· 3 shared L. Song· 3 shared B. Hong· 2 shared H. Zhuang· 2 shared K. Xiang· 2 shared S. Luo· 2 shared T. Li· 2 shared X. An· 2 shared

Activity by Year

2019-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

H. Fan

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3'-terminus untranslated region

S. Lu, S. Luo, C. Liu, M. Li, X. An, M. Li, J. Hou, H. Fan, P. Mao, Y.-G. Tong, L. Song

This study identifies a highly attenuated SARS-CoV-2 related pangolin coronavirus variant with a 104nt deletion in the 3'-UTR HVR, showing reduced virulence in vitro and in vivo.

bioRxiv · Feb 7, 2022 · PreprintMicrobiology

SARS-CoV-2 and Malayan pangolin coronavirus infect human endoderm, ectoderm and induced lung progenitor cells

K. Xiang, B. Hong, X. Lai, Y. Chen, T. Luo, X. An, L. Song, H. Zhuang, H. Fan, T. Li, Y.-G. Tong

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

bioRxiv · Sep 25, 2020 · PreprintMicrobiology

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

M. Cheng, Z. Cheng, Y. Yu, W. Liu, R. Li, Z. Guo, J. Qin, Z. Zeng, L. Di, Y. Mo, C. Pan, Y. Liang, J. Li, Y.-G. Tong, Y. Yan, , K. Ning

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

bioRxiv · Sep 15, 2020 · PreprintBioengineering

The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro

H. Fan, Y. Luo, B. Hong, L. Wang, X. Jin, Y. Chen, Y. Hu, T. Li, H. Zhuang, Y.-H. Zhou, Y.-G. Tong, K. Xiang

This study shows that whey protein from human and other animal milk inhibits SARS-CoV-2 and GX_P2V in vitro by blocking viral attachment, entry, and replication.

bioRxiv · Aug 17, 2020Microbiology

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19

B.-z. Zhang, Y.-f. Hu, L.-l. Chen, Y.-g. Tong, J.-c. Hu, J.-p. Cai, K.-H. Chan, Y. Dou, J. Deng, H.-r. Gong, C. Kuwentrai, W. Li, X.-l. Wang, H. Chu, C.-h. Su, , J.-D. Huang

This study maps immunodominant sites on the SARS-CoV-2 spike protein using patient sera to identify potential vaccine candidates and demonstrates their neutralizing activity in mice.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology

Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China

T. T.-Y. Lam, M. H.-H. Shum, H.-C. Zhu, Y.-G. Tong, X.-B. Ni, Y.-S. Liao, W. Wei, W. Y.-M. Cheung, W.-J. Li, L.-F. Li, G. M. Leung, E. C. Holmes, Y.-L. Hu, Y. Guan

The paper identifies 2019-nCoV related coronaviruses in Malayan pangolins, suggesting they may be intermediate hosts for the virus.

bioRxiv · Feb 13, 2020Microbiology

Culture under normoxic conditions and enhanced virulence of phase II Coxiella burnetii transformed with a RSF1010-based shuttle vector

S. Luo, Z. He, Z. Sun, Y. Yu, Y. Jiang, Y.-G. Tong, L. Song

This study shows that Coxiella burnetii phase II can grow under normoxic conditions in ACCM-2 with tryptophan, and its transformant grows robustly without tryptophan, suggesting tryptophan and a temperature-sensitive signal are involved in normoxic growth.

bioRxiv · Aug 28, 2019 · PreprintMicrobiology