Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites
L. Dirkx, S. Van Acker, Y. Nicolaes, J. L. R. Cunha, R. Ahmad, B. Caljon, H. Imamura, D. G. Ebo, D. Jeffares, Y. G.-J. Sterckx, L. Maes, S. Hendrickx, G. Caljon
This study shows that Leishmania parasites enter quiescence after 4-6 divisions in hematopoietic stem cells, enabling drug resistance and increased infectivity.
bioRxiv · Aug 23, 2023 · PreprintMicrobiology