Chromosomal Duplications of MurZ (MurA2) or MurA (MurA1), Amino Acid Substitutions in MurZ (MurA2), and Absence of KhpAB Obviate the Requirement for Protein Phosphorylation in Streptococcus pneumoniae D39
H.-C. T. Tsui, M. Joseph, J. J. Zheng, A. J. Perez, I. Manzoor, B. E. Rued, J. D. Richardson, P. Branny, L. Doubravova, O. Massidda, M. E. Winkler
The paper identifies genetic modifications in Streptococcus pneumoniae that bypass the need for protein phosphorylation by altering MurZ and MurA activity.
bioRxiv · Mar 26, 2023Microbiology