Author

M. Joseph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Cancer Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Organism:human· 4 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H.-C. T. Tsui· 2 shared I. Manzoor· 2 shared M. E. Winkler· 2 shared O. Massidda· 2 shared A. C. Hayday· 1 shared A. G. Laing· 1 shared A. J. Perez· 1 shared A. Malek· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

H.-C. T. Tsui

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik.

B. Rambaud, M. Joseph, F.-C. Tsai, C. V. De Jamblinne, E. Del Guidice, R. Sabelli, P. Bassereau, D. R. Hipfner, S. Carreno

This study identifies STRIPAK's role in promoting cytoneme biogenesis through Slik's membrane-sculpting function, which drives cell proliferation in Drosophila.

bioRxiv · Mar 4, 2024 · PreprintCell Biology

Preserving endothelial integrity in human saphenous veins during preparation for coronary bypass surgery

M. W. Sedovy, X. Leng, F. Iqbal, M. C. Renton, M. Leaf, K. Roberts, A. Malek, W. S. Arnold, D. A. Wyatt, C. W. Choate, J. F. Rowe, J. W. Baker, S. R. Johnstone, M. Joseph

This study compares heparinized saline and blood solutions for preserving saphenous vein endothelium during coronary bypass graft preparation, finding blood better preserves endothelial integrity and reduces oxidative stress.

bioRxiv · Aug 25, 2023Physiology

Bronchoconstriction damages airway epithelia by excess crowding-induced extrusion

D. C. Bagley, T. Russell, E. Ortiz-Zapater, K. Fox, P. F. Redd, M. Joseph, C. D. Rice, C. A. Reilly, M. Parsons, J. Rosenblatt

This study shows that bronchoconstriction causes epithelial cell extrusion, leading to airway damage, inflammation, and mucus secretion, and that inhibiting extrusion prevents these symptoms.

bioRxiv · Aug 4, 2023 · PreprintCell Biology

Chromosomal Duplications of MurZ (MurA2) or MurA (MurA1), Amino Acid Substitutions in MurZ (MurA2), and Absence of KhpAB Obviate the Requirement for Protein Phosphorylation in Streptococcus pneumoniae D39

H.-C. T. Tsui, M. Joseph, J. J. Zheng, A. J. Perez, I. Manzoor, B. E. Rued, J. D. Richardson, P. Branny, L. Doubravova, O. Massidda, M. E. Winkler

The paper identifies genetic modifications in Streptococcus pneumoniae that bypass the need for protein phosphorylation by altering MurZ and MurA activity.

bioRxiv · Mar 26, 2023Microbiology

Extracellular ATP drives pancreatic cancer cell invasion via purinergic receptor-integrin interactions

E. Tomas Bort, M. Joseph, Q. Wang, E. Carter, N. Roth, J. Gibson, A. Samadi, H. Kocher, S. Simoncelli, P. J. McCormick, R. P. Grose

This study identifies P2RY2 as a key purinergic receptor involved in pancreatic cancer invasion through interactions with integrins, suggesting therapeutic targeting potential.

bioRxiv · Oct 24, 2022Cancer Biology

Roles of RodZ and Class A PBP1b in the Assembly and Regulation of the Peripheral Peptidoglycan Elongasome in Ovoid-Shaped Cells of Streptococcus pneumoniae D39

M. M. Lamanna, I. Manzoor, M. Joseph, Z. A. Ye, M. Benedet, A. Zanardi, Z. Ren, X. Wang, O. Massidda, H.-C. T. Tsui, M. E. Winkler

This study investigates the role of RodZ and PBP1b in the PG elongasome of ovoid-shaped Streptococcus pneumoniae, showing RodZ as a scaffolding protein and PBP1b's involvement in elongasome regulation.

bioRxiv · Jun 1, 2022Microbiology

Impact of the B.1.1.7 variant on neutralizing monoclonal antibodies recognizing diverse epitopes on SARS-CoV-2 Spike

C. Graham, J. Seow, I. Huettner, H. Khan, N. Kouphou, S. Acors, H. Winstone, S. Pickering, R. Pedro Galao, M. Jose Lista, J. M. Jimenez-Guardeno, A. G. Laing, Y. Wu, M. Joseph, L. Muir, , K. J. Doores

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

bioRxiv · Feb 3, 2021 · PreprintImmunology